Computing Fractional Flow Reserve From Invasive Coronary Angiography

Computed Fractional Flow Reserve (FFTCT) Derived from Coronary CT Angiography

Recent advances in image-based modeling and computational fluid dynamics permit the calculation of coronary artery pressure and flow from typically acquired coronary computed tomography (CT) scans. Computed fractional flow reserve is the ratio of mean coronary artery pressure divided by mean aortic pressure under conditions of simulated maximal coronary hyperemia, thus providing a noninvasive e...

Virtual fractional flow reserve from coronary angiography: modeling the significance of coronary lesions: results from the VIRTU-1 (VIRTUal Fractional Flow Reserve From Coronary Angiography) study.

OBJECTIVES The aim of this study was to develop a computer model that accurately predicts myocardial fractional flow reserve (FFR) from angiographic images alone, in patients with coronary artery disease. BACKGROUND Percutaneous coronary intervention (PCI) guided by FFR is superior to standard assessment alone. FFR-guided PCI results in improved clinical outcomes, a reduction in the number of...

Cost analysis of non-invasive fractional flow reserve derived from coronary computed tomographic angiography in Japan

Percutaneous coronary intervention (PCI) based on fractional flow reserve (FFRcath) measurement during invasive coronary angiography (CAG) results in improved patient outcome and reduced healthcare costs. FFR can now be computed non-invasively from standard coronary CT angiography (cCTA) scans (FFRCT). The purpose of this study is to determine the potential impact of non-invasive FFRCT on costs...

Coronary Computed Tomography Angiography With Selective Noninvasive Fractional Flow Reserve

Visual-functional mismatch between coronary angiography and fractional flow reserve.

OBJECTIVES The goal of this study was to identify clinical and lesion-specific local factors affecting visual-functional mismatch. BACKGROUND Although lesion severity determined by coronary angiography has not been well correlated with physiological significance, the mechanism of the discordance remains poorly understood. METHODS The authors assessed quantitative coronary angiography, intra...